Table of Contents

INTRODUCTION

ALDOSTERONE BIOSYNTHESIS

REGULATION OF ALDOSTERONE SECRETION

The Renin-Angiotensin system

Potassium

Pituitary Factors

Sodium

Inhibitory agents

MECHANISMS OF ALDOSTERONE ACTION

Effect of Aldosterone

Mineralocorticoid Receptor

Molecular and Cellular Mechanisms of the Aldosterone Action

Pre-receptor Regulation

Amiloride-sensitive sodium channel

CLASSIFICATION OF HYPOALDOSTERONISM

Defective Stimulation of Aldosterone

Primary Defects in Adrenal Biosynthesis or Secretion of Aldosterone

Defective Aldosterone Actions

HYPORENINEMIC HYPOALDOSTERONISM

Presentation

Pathophysiology

Diagnosis

Therapy

PRIMARY HYPOALDOSTERONISM

(Aldosterone Synthase) Deficiency

Acquired form of primary hypoaldosteronism

TYPE 1 (ALDOSTERONE RESISTANCE )

Clinical Presentation

Pathophysiology

Diagnosis

Therapy

Molecular Mechanism(s) of Pseudohypoaldosteronism