Hyperhidrosis of the upper body, often related to eating (gustatory sweating) and anhidrosis of the lower body, is a characteristic feature of autonomic neuropathy. Gustatory sweating accompanies the ingestion of certain foods, particularly spicy foods, and cheeses. There is a suggestion that application of glycopyrrolate (antimuscarinic compound) might benefit diabetic patients with gustatory sweating (177). Low-dose oral glycopyrrolate in the dose of 1 mg to 2 mg once daily can be tolerated without problematic adverse effects to alleviate the symptoms of the diabetic gustatory sweating. Although more long-term data are needed, the use of glycopyrrolate for diabetic gustatory sweating may be a viable option (178). Symptomatic relief can be obtained by avoiding the specific inciting food. Loss of lower body sweating can cause dry, brittle skin that cracks easily, predisposing one to ulcer formation that can lead to loss of the limb. Special attention must be paid to foot care.