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140. Melia WM, Nunnerley HB, Johnson PJ, Williams R: Use of arterial devascularization and cytotoxic drugs in 30 patients with the carcinoid syndrome. Br J Cancer 46:331-339, 1982

141. Kvols LK, Buck M: Chemotherapy of endocrine malignancies: a review. Semin Oncol 14:343-353, 1987

142. Bukowski RM, Tangen CM, Peterson RF, Taylor SA, Rinehart JJ, Eyre HJ, Rivkin SE, Fleming TR, Macdonald JS: Phase II trial of dimethyltriazenoimidazole carboxamide in patients with metastatic carcinoid. A Southwest Oncology Group study. Cancer 73:1505-1508, 1994

143. Moertel CG, Rubin J, O'Connell MJ: Phase II study of cisplatin therapy in patients with metastatic carcinoid tumor and the malignant carcinoid syndrome. Cancer Treat Rep 70:1459-1460, 1986

144. Kelsen D, Fiore J HRCEMG: Phase II trial of etoposide in APUD tumors. Cancer Treat Rep 71:305-307, 1987

145. Mengel C E, Shaffer RD: The carcinoid syndrome. In Cancer Medicine 1973

146. Engstrom PF, Lavin PT, Moertel CG, Folsch E, Douglass HO, Jr.: Streptozocin plus fluorouracil versus doxorubicin therapy for metastatic carcinoid tumor. J Clin Oncol 2:1255-1259, 1984

147. Bukowski RM, Johnson KG, Peterson RF, Stephens RL, Rivkin SE, Neilan B, Costanzi JH: A phase II trial of combination chemotherapy in patients with metastatic carcinoid tumors. A Southwest Oncology Group Study. Cancer 60:2891-2895, 1987

148. Oberg K, Norheim I, Alm G: Treatment of malignant carcinoid tumors: a randomized controlled study of streptozocin plus 5-FU and human leukocyte interferon. Eur J Cancer Clin Oncol 25:1475-1479, 1989

149. Feldman JM: Carcinoid tumors and the carcinoid syndrome. Curr Probl Surg 26:835-885, 1989

150. Mendel DB, Laird AD, Xin X, Louie SG, Christensen JG, Li G, Schreck RE, Abrams TJ, Ngai TJ, Lee LB, Murray LJ, Carver J, Chan E, Moss KG, Haznedar JO, Sukbuntherng J, Blake RA, Sun L, Tang C, Miller T, Shirazian S, McMahon G, Cherrington JM: In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship. Clin Cancer Res 9:327-337, 2003

151. Abrams TJ, Lee LB, Murray LJ, Pryer NK, Cherrington JM: SU11248 inhibits KIT and platelet-derived growth factor receptor beta in preclinical models of human small cell lung cancer. Mol Cancer Ther 2:471-478, 2003

152. Sarbassov DD, Ali SM, Sabatini DM: Growing roles for the mTOR pathway. Curr Opin Cell Biol 17:596-603, 2005

153. Kiepe D, Ciarmatori S, Hoeflich A, Wolf E, Tonshoff B: Insulin-like growth factor (IGF)-I stimulates cell proliferation and induces IGF binding protein (IGFBP)-3 and IGFBP-5 gene expression in cultured growth plate chondrocytes via distinct signaling pathways. Endocrinology 146:3096-3104, 2005

154. Ha CH, Bennett AM, Jin ZG: A novel role of vascular endothelial cadherin in modulating c-Src activation and downstream signaling of vascular endothelial growth factor. J Biol Chem 2008

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156. Smolewski P: Recent developments in targeting the mammalian target of rapamycin (mTOR) kinase pathway. Anticancer Drugs 17:487-494, 2006

157. Duran I, Kortmansky J, Singh D, Hirte H, Kocha W, Goss G, Le L, Oza A, Nicklee T, Ho J, Birle D, Pond GR, Arboine D, Dancey J, viel-Ronen S, Tsao MS, Hedley D, Siu LL: A phase II clinical and pharmacodynamic study of temsirolimus in advanced neuroendocrine carcinomas. Br J Cancer 95:1148-1154, 2006

158. Yao JC, Phan A, Chang DZ, Wolff RA, Jacobs C, Mares JE, Gupta S, Meric-Bernstam F, Rashid A: Phase II study of RAD001 (everolimus) and depot octreotide (sandostatin LAR) in patients with advanced low grade neuroendocrine carcinoma (LGNET) (Abstract). Journal of Clinical Oncology 25: 2007

159. Grozinsky-Glasberg S, Franchi G, Teng M, Leontiou CA, Ribeiro de OA, Jr., Dalino P, Salahuddin N, Korbonits M, Grossman AB: Octreotide and the mTOR Inhibitor RAD001 (Everolimus) Block Proliferation and Interact with the Akt-mTOR-p70S6K Pathway in a Neuro-Endocrine Tumour Cell Line. Neuroendocrinology 2007

160. Awada A, Cardoso F, Fontaine C, Dirix L, De GJ, Sotiriou C, Steinseifer J, Wouters C, Tanaka C, Zoellner U, Tang P, Piccart M: The oral mTOR inhibitor RAD001 (everolimus) in combination with letrozole in patients with advanced breast cancer: Results of a phase I study with pharmacokinetics. Eur J Cancer 44:84-91, 2008

161. Oberg K, Eriksson B: Medical treatment of neuroendocrine gut and pancreatic tumors. Acta Oncol 28:425-431, 1989

162. Hanssen LE, Schrumpf E, Kolbenstvedt AN, Tausjo J, Dolva LO: Treatment of malignant metastatic midgut carcinoid tumours with recombinant human alpha2b interferon with or without prior hepatic artery embolization. Scand J Gastroenterol 24:787-795, 1989

163. Sisson J C, Hutchinson RJ JJ: Acute toxicity of therapeutic I-131-MIBG relates more to whole body than to blood radiation dosimetry. J Nucl Med 23:618, 1987

164. Oberg K: The action of interferon alpha on human carcinoid tumours. Semin Cancer Biol 3:35-41, 1992

165. Moertel CG, Rubin J, Kvols LK: Therapy of metastatic carcinoid tumor and the malignant carcinoid syndrome with recombinant leukocyte A interferon. J Clin Oncol 7:865-868, 1989

166. Ajani J, Carrasco C CC: Islet cell tumors metastatic to the liver: effective palliation by seuential hepatic artery embolization. Proc Am Soc Clin Oncol 4:80, 1989

167. Moertel C G, May GR MJRJSA: Sequential hepatic artery occlusion (HAO. and chemotherapy for metastic carcinoid tumor and islet cell carcinoma. Proc Am Soc Clin Oncol 4:80, 1985